From Hattiesburg Airport:
Leaving Hattiesburg/Laurel airport take – I-59 North to Laurel exit. Stay on I-59 until you reach Exit 95B. Take that exit, you will be on 16th Avenue. You will take a right on Jefferson Street. (Waffle House will be on your Left.) Drive 1/4 mile and South Central  will be on your right.

From Jackson Airport:
Leaving the airport, take the I-20 West Exit. Travel 3 miles. Take the Hwy. 49 South (Hattiesburg) Exit. Travel 63 miles to Collins. Take the Hwy. 84 East Exit in Collins. Take a left and travel east towards Laurel. As you arrive in Laurel you will take a right at the first major intersection which is the intersection of 16th Ave. and Hwy 84. At the next light (Jefferson Street) you will take a left. Shoney’s will be on your right. MEA Clinic will be on your left. As you go through the 1st stop sign, the medical center will be on your right.

Directions from New Orleans to South Central Regional Medical Center.
Leaving New Orleans – Take I-10 East to I-59 North (Exit 267 towards Hattiesburg) Stay on I-59 until you reach Exit 95B. Take that exit, you will be on 16th Avenue. At the first stop light you will need to take a right onto Jefferson Street. Shoney’s will be on your left and MEA Clinic will be on the corner. Drive one block and the medical center will be on your right.

South Central Regional Medical Center
1220 Jefferson St.
Laurel, MS 39440
(601) 426-4000